Our main aim is to design and construct functional molecules. We are particularly interested in molecular system which are able to respond to a stimulus, which triggers a cascade of events, ending up with the desired task. However our lab philosophy is to be always open to new ideas and projects.
Here is a brief description of what we do:
Smart drug carriers.
Targeted delivery approach is the long sought aim of drug delivery. In this regard, we have designed and built several nano-carriers in order to transport and release compounds specifically under a biologically relevant stimulus.
Pro-drugs for cancer and neurodegenerative diseases.
Traditional cancer chemotherapy lacks any intrinsic selectivity and it is very often accompanied by systemic toxicity to the patient. To circunvent such an inconvenience, we have made novel pro-drugs which are activated under specific conditions on the tumoral micro-environment.
At the same time, we have developed multitarget pro-drugs for neurodegenerative diseases such as Alzheimer’s or Huntington’s.
Detecting a specific compounds among a plethora of other molecules is highly relevant in biomedical research and in several other fields. Additionally it is a truly scientific challenge. We are developing supramolecular systems and materials for detection of interesting compound by fluorescence. We study the photophysical properties and we extend the research towards theranostics.
Fullerene based systems.
We are trying to take advantage of the particular properties of Fullerenes, and apply them to supramolecular systems.
Greener synthetic methodologies.
Sustainable development has increasingly become a top priority for several governments and industries. Our aim is to replace toxic reagents in specific chemical reactions for non-toxic affordable reagents.
Novel methods of preservation of paper.
About one third of the paper items in large libraries are too brittle to handle, with another third in need of attention over the coming century. It may sound irrelevant or unimportant, but most of the culture, the knowledge and the heritage of humanity lies on paper which is in danger. Chemists can definitely play a vital role on heritage preservation because, in the end, it is all about Chemistry. We have approached paper degradation as if it was a disease, and we have made several pro-drug-like preservants for historical paper documents.